UHealth - University of Miami Health System

E-mail a Friend

Ernesto Bernal-Mizrachi, M.D.

General Information

Ernesto  Bernal-Mizrachi, M.D.



  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine



Clinical Areas

 Diabetes Type 1 & Type 2, Rare form genetic diabetes


  • American Bd of Int Med-Endocrinology Diabetes & Metabolism


  • Chief, Division of Endocrinology
  • Professor of Medicine

Research Interests

Dr. Bernal-Mizrachi's research over the last 15 years has focused on the regulation of pancreatic beta cell mass and function, with a particular interest in Akt and mTOR signaling pathways in beta cell proliferation. His laboratory has made major contributions to our understanding of signaling pathways that regulate beta cell expansion and survival. The long term goal of these signaling studies is to develop novel pharmacological agents for the treatment and cure of type 1 and 2 diabetes. In addition, his laboratory also explores how the fetal environment can alter the susceptibility to diabetes later in life, a concept that has major implications to human diabetes. Finally, his group has been exploring the importance of glucagon and alpha cells in the regulation of glucose homeostasis with particular interest in discovering avenues to decrease hypoglycemia in diabetes. He has an excellent record of grant funding and currently is principal investigator on RO1 grants from the National Institutes of Health, a VA MERIT award and two foundation grants including American Diabetes Association and Juvenile Diabetes Research Foundation.



Dr. Ernesto Bernal-Mizrachi is a Professor of internal medicine and Chief of the Division of Endocrinology, Diabetes and Metabolism in the University of Miami Miller School of Medicine. He is also a physician at the Miami Veterans Administration Hospital. Dr. Bernal-Mizrachi received his medical degree from the Universidad del Valle Medical School in Cali, Colombia, and also completed an internal medicine residency there. He received additional residency training in internal medicine at the University of Miami, followed by a three-year fellowship in endocrinology and metabolism at Washington University in St. Louis. He joined Washington University faculty in 1999 and held the academic titles of assistant professor of medicine and assistant professor of cell biology from 2004, until 2009 when he moved to Michigan to assume the Soderquist Professorship. In 2015, he moved to the University of Miami as Chief of the Division of Endocrinology, Diabetes and Metabolism and Deputy Director for Signal Transduction at the Diabetes Research Institute. 
Dr. Bernal-Mizrachi has been consistently active in postdoctoral education and has served on the fellowship Training Steering Committee at Washington University and The University of Michigan. In addition, he has served on study sections and review panels for the National Institutes of Health and the Juvenile Diabetes Research Foundation. He is also a member of the editorial board of Molecular Endocrinology, the American Journal of Physiology- Endocrinology and Metabolism and ad hoc reviewer for various specialty journals including, Diabetes, Cell Metabolism, Diabetologia, Nature Medicine, Scientific Reports, Science, Gastroenterology, the Journal of Clinical Investigation, Cell Metabolism and Annual Review of Physiology. Dr. Bernal-Mizrachi has received many awards including a Junior Faculty Award and a Career Development Award from the American Diabetes Association and he was elected a member of the American Society for Clinical Investigation (ASCI).

E-mail a Friend